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1

Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework

Hanf, Karl J.M., Arndt, Joseph W., Chen, Ling Ling, Jarpe, Matthew, Boriack-Sjodin, P. Ann, Li, You, van Vlijmen, Herman W.T., Pepinsky, R. Blake, Simon, Kenneth J., Lugovskoy, Alexey

Journal:

Year:

2014

Language:

english

File:

PDF, 1.39 MB

english, 2014

2

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Chan-Penebre, Elayne, Kuplast, Kristy G, Majer, Christina R, Boriack-Sjodin, P Ann, Wigle, Tim J, Johnston, L Danielle, Rioux, Nathalie, Munchhof, Michael J, Jin, Lei, Jacques, Suzanne L, West, Kip A,

Journal:

Nature Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.52 MB

english, 2015

3

RNA-modifying proteins as anticancer drug targets

Boriack-Sjodin, P. Ann, Ribich, Scott, Copeland, Robert A.

Journal:

Nature Reviews Drug Discovery

Year:

2018

Language:

english

File:

PDF, 3.27 MB

english, 2018

4

2-Aminoimidazoles inhibitors of TGF-β receptor 1

Dominique Bonafoux, Claudio Chuaqui, P. Ann Boriack-Sjodin, Chris Fitch, Gretchen Hankins, Serene Josiah, Cheryl Black, Gregg Hetu, Leona Ling, Wen-Cherng Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 247 KB

english, 2009

5

Successful shape-Based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)

Juswinder Singh, Claudio E. Chuaqui, P.Ann Boriack-Sjodin, Wen-Cherng Lee, Timothy Pontz, Michael J. Corbley, H.-Kam Cheung, Robert M. Arduini, Jonathan N. Mead, Miki N. Newman, James L. Papadatos, Sc

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 281 KB

english, 2003

6

Corrigendum to “Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)”: [Bioorg. Med. Chem. Lett. 13 (2003) 4355]

Juswinder Singh, Claudio E. Chuaqui, P. Ann Boriack-Sjodin, Wen-Cherng Lee, Timothy Pontz, Michael J. Corbley, H.-Kam Cheung, Robert M. Arduini, Jonathan N. Mead, Miki N. Newman, James L. Papadatos, S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 206 KB

english, 2004

7

Structure–activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors

Edward Yin-Shiang Lin, Kevin M. Guckian, Laura Silvian, Donovan Chin, P. Ann Boriack-Sjodin, Herman van Vlijmen, Jessica E. Friedman, Daniel M. Scott

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 381 KB

english, 2008

8

Pyrazolone based TGFβR1 kinase inhibitors

Kevin Guckian, Mary Beth Carter, Edward Yin-Shiang Lin, Michael Choi, Lihong Sun, P. Ann Boriack-Sjodin, Claudio Chuaqui, Benjamin Lane, Kam Cheung, Leona Ling, Wen-Cherng Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 630 KB

english, 2010

9

Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: Molecular basis of isozyme-drug discrimination

Travis Stams, Yun Chen, David W. Christianson, P. Ann Boriack-Sjodin, Jonathan D. Hurt, Philip Laipis, David N. Silverman, John Liao, Jesse A. May, Tom Dean

Journal:

Protein Science

Year:

1998

Language:

english

File:

PDF, 7.92 MB

english, 1998

10

Structural analysis of inhibitor binding to human carbonic anhydrase II

P. Ann Boriack-Sjodin, Samantha Zeitlin, David W. Christianson, Huang-Hsing Chen, Lori Crenshaw, Sharon Gross, Anura Dantanarayana, Pete Delgado, Jesse A. May, Tom Dean

Journal:

Protein Science

Year:

1998

Language:

english

File:

PDF, 7.19 MB

english, 1998

11

10.1038/28548

Boriack-Sjodin, P. Ann, Margarit, S. Mariana, Bar-Sagi, Dafna, Kuriyan, John

Journal:

Year:

1998

Language:

english

File:

PDF, 643 KB

english, 1998

12

Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design

Louis A. Clark, P. Ann Boriack-Sjodin, John Eldredge, Christopher Fitch, Bethany Friedman, Karl J.M. Hanf, Matthew Jarpe, Stefano F. Liparoto, You Li, Alexey Lugovskoy, Stephan Miller, Mia Rushe, Wood

Journal:

Protein Science

Year:

2006

Language:

english

File:

PDF, 425 KB

english, 2006

13

Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes

Michael Karpusas, Teresa G Cachero, Fang Qian, Ann Boriack-Sjodin, Colleen Mullen, Kathy Strauch, Yen-Ming Hsu, Susan L Kalled

Journal:

Journal of Molecular Biology

Year:

2002

Language:

english

File:

PDF, 517 KB

english, 2002

14

Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV

John I. Manchester, Daemian D. Dussault, Jonathan A. Rose, P. Ann Boriack-Sjodin, Maria Uria-Nickelsen, Georgine Ioannidis, Shanta Bist, Paul Fleming, Kenneth G. Hull

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.47 MB

english, 2012

15

In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound

Keating, Thomas A., Newman, Joseph V., Olivier, Nelson B., Otterson, Linda G., Andrews, Beth, Boriack-Sjodin, P. Ann, Breen, John N., Doig, Peter, Dumas, Jacques, Gangl, Eric, Green, Oluyinka M., Gule

Journal:

ACS Chemical Biology

Year:

2012

Language:

english

File:

PDF, 3.65 MB

english, 2012

16

Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy

Brian A. Sherer, Kenneth Hull, Oluyinka Green, Gregory Basarab, Sheila Hauck, Pamela Hill, James T. Loch III, George Mullen, Shanta Bist, Joanna Bryant, Ann Boriack-Sjodin, Jon Read, Nancy DeGrace, Ma

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 417 KB

english, 2011

17

Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK)

Martínez-Botella, Gabriel, Loch, James T., Green, Oluyinka M., Kawatkar, Sameer P., Olivier, Nelson B., Boriack-Sjodin, P. Ann, Keating, Thomas A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.64 MB

english, 2013

18

Fragment-to-Hit-to-Lead Discovery of a Novel Pyridylurea Scaffold of ATP Competitive Dual Targeting Type II Topoisomerase Inhibiting Antibacterial Agents

Basarab, Gregory S., Manchester, John I., Bist, Shanta, Boriack-Sjodin, P. Ann, Dangel, Brian, Illingworth, Ruth, Sherer, Brian A., Sriram, Shubha, Uria-Nickelsen, Maria, Eakin, Ann E.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 4.58 MB

english, 2013

19

Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor

Basavapathruni, Aravind, Olhava, Edward J., Daigle, Scott R., Therkelsen, Carly A., Jin, Lei, Boriack-Sjodin, P. Ann, Allain, Christina J., Klaus, Christine R., Raimondi, Alejandra, Scott, Margaret Po

Journal:

Biopharmaceutics & Drug Disposition

Year:

2014

Language:

english

File:

PDF, 770 KB

english, 2014

20

Corrigendum to “Identification through structure-based methods of a bacterial NAD+-dependent DNA ligase inhibitor that avoids known resistance mutations” [Bioorg. Med. Chem. Lett. 24 (2014) 360–366]

Murphy-Benenato, Kerry, Wang, Hongming, McGuire, Helen M., Davis, Hajnalka E., Gao, Ning, Bryan Prince, D., Jahic, Haris, Stokes, Suzanne S., Ann Boriack-Sjodin, P.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 491 KB

english, 2014

21

Identification through structure-based methods of a bacterial NAD+-dependent DNA ligase inhibitor that avoids known resistance mutations

Murphy-Benenato, Kerry, Wang, Hongming, McGuire, Helen M., Davis, Hajnalka E., Gao, Ning, Prince, D. Bryan, Jahic, Haris, Stokes, Suzanne S., Boriack-Sjodin, P. Ann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.41 MB

english, 2014

22

Structure-Based Design of an Intramolecular Proton Transfer Site in Murine Carbonic Anhydrase V †

Heck, Robert W., Boriack-Sjodin, P. Ann, Qian, Minzhang, Tu, Chingkuang, Christianson, David W., Laipis, Philip J., Silverman, David N.

Journal:

Year:

1996

Language:

english

File:

PDF, 342 KB

english, 1996

23

Artemin Crystal Structure Reveals Insights into Heparan Sulfate Binding ‡

Silvian, Laura, Jin, Ping, Carmillo, Paul, Boriack-Sjodin, P. Ann, Pelletier, Carolyn, Rushe, Mia, Gong, BangJian, Sah, Dinah, Pepinsky, Blake, Rossomando, Anthony

Journal:

Year:

2006

Language:

english

File:

PDF, 1.04 MB

english, 2006

24

Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping

Doig, Peter, Boriack-Sjodin, P. Ann, Dumas, Jacques, Hu, Jun, Itoh, Kenji, Johnson, Kenneth, Kazmirski, Steven, Kinoshita, Tomohiko, Kuroda, Satoru, Sato, Tomo-o, Sugimoto, Kaori, Tohyama, Katsumi, Ao

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 3.65 MB

english, 2014

25

An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode

Larsen, Nicholas A., Nash, Tory J., Morningstar, Marshall, Shapiro, Adam B., Joubran, Camil, Blackett, Carolyn J., Patten, Arthur D., Boriack‑Sjodin, P. Ann, Doig, Peter

Journal:

Biochemical Journal

Year:

2012

Language:

english

File:

PDF, 1.78 MB

english, 2012

26

Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology

Johannes, Jeffrey W., Almeida, Lynsie, Barlaam, Bernard, Boriack-Sjodin, P. Ann, Casella, Robert, Croft, Rosemary A., Dishington, Allan P., Gingipalli, Lakshmaiah, Gu, Chungang, Hawkins, Janet L., Hol

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.32 MB

english, 2015

27

Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound

Mitchell, Lorna H., Drew, Allison E., Ribich, Scott A., Rioux, Nathalie, Swinger, Kerren K., Jacques, Suzanne L., Lingaraj, Trupti, Boriack-Sjodin, P. Ann, Waters, Nigel J., Wigle, Tim J., Moradei, Os

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.23 MB

english, 2015

28

Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor

Mitchell, Lorna H., Boriack-Sjodin, P. Ann, Smith, Sherri, Thomenius, Michael, Rioux, Nathalie, Munchhof, Michael, Mills, James E., Klaus, Christine, Totman, Jennifer, Riera, Thomas V., Raimondi, Alej

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.34 MB

english, 2015

29

Negishi Cross-Coupling Enabled Synthesis of Novel NAD+-Dependent DNA Ligase Inhibitors and SAR Development

Murphy-Benenato, Kerry E., Gingipalli, Lakshmaiah, Ann Boriack-Sjodin, P., Martinez-Botella, Gabriel, Carcanague, Dan, Eyermann, Charles J., Gowravaram, Madhu, Harang, Jenna, Hale, Michael R., Ioannid

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

File:

PDF, 1.22 MB

2015

30

Negishi Cross-Coupling Enabled Synthesis of Novel NAD+-Dependent DNA Ligase Inhibitors and SAR Development

Murphy-Benenato, Kerry E., Gingipalli, Lakshmaiah, Ann Boriack-Sjodin, P., Martinez-Botella, Gabriel, Carcanague, Dan, Eyermann, Charles J., Gowravaram, Madhu, Harang, Jenna, Hale, Michael R., Ioannid

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.22 MB

english, 2015

31

Structure Determination of Murine Mitochondrial Carbonic Anhydrase V at 2.45-Å Resolution: Implications for Catalytic Proton Transfer and Inhibitor Design

P. Ann Boriack-Sjodin, Robert W. Heck, Philip J. Laipis, David N. Silverman and David W. Christianson

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1017 KB

english, 1995

32

Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates

Boriack-Sjodin, P. Ann, Jin, Lei, Jacques, Suzanne L., Drew, Allison, Sneeringer, Chris, Scott, Margaret Porter, Moyer, Mikel P., Ribich, Scott, Moradei, Oscar, Copeland, Robert A.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 8.25 MB

english, 2015

33

Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666

Duncan, Kenneth W., Rioux, Nathalie, Boriack-Sjodin, P. Ann, Munchhof, Michael J., Reiter, Lawrence A., Majer, Christina R., Jin, Lei, Johnston, L. Danielle, Chan-Penebre, Elayne, Kuplast, Kristy G.,

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.88 MB

english, 2015

34

Protein methyltransferases: A distinct, diverse and dynamic family of enzymes

Boriack-Sjodin, P. Ann, Swinger, Kerren K

Journal:

Year:

2015

Language:

english

File:

PDF, 1.64 MB

english, 2015

35

CARM1 Preferentially Methylates H3R17 over H3R26 through a Random Kinetic Mechanism

Jacques, Suzanne L., Aquino, Katrina P., Gureasko, Jodi, Boriack-Sjodin, P. Ann, Porter Scott, Margaret, Copeland, Robert A., Riera, Thomas V.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.11 MB

english, 2016

36

Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP

Basavapathruni, Aravind, Gureasko, Jodi, Porter Scott, Margaret, Hermans, William, Godbole, Adarsh, Leland, Peter A., Boriack-Sjodin, P. Ann, Wigle, Tim J., Copeland, Robert A., Riera, Thomas V.

Journal:

Year:

2016

Language:

english

File:

PDF, 354 KB

english, 2016

37

The Elements of Translational Chemical Biology

Copeland, Robert A., Boriack-Sjodin, P. Ann

Journal:

Cell Chemical Biology

Year:

2017

Language:

english

File:

PDF, 807 KB

english, 2017

38

Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma

Drew, Allison E., Moradei, Oscar, Jacques, Suzanne L., Rioux, Nathalie, Boriack-Sjodin, Ann P., Allain, Christina, Scott, Margaret Porter, Jin, Lei, Raimondi, Alejandra, Handler, Jessica L., Ott, Heid

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 5.08 MB

english, 2017

39

Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing

Gerhart, Sarah V., Kellner, Wendy A., Thompson, Christine, Pappalardi, Melissa B., Zhang, Xi-Ping, Montes de Oca, Rocio, Penebre, Elayne, Duncan, Kenneth, Boriack-Sjodin, Ann, Le, BaoChau, Majer, Chri

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 2.48 MB

english, 2018

40

Identification of a peptide inhibitor for the histone methyltransferase WHSC1

Morrison, Michael J., Boriack-Sjodin, P. Ann, Swinger, Kerren K., Wigle, Tim J., Sadalge, Dipti, Kuntz, Kevin W., Scott, Margaret Porter, Janzen, William P., Chesworth, Richard, Duncan, Kenneth W., Ha

Journal:

Year:

2018

Language:

english

File:

PDF, 3.20 MB

english, 2018

41

A Mass Spectrometric Assay of METTL3/METTL14 Methyltransferase Activity

Buker, Shane M., Gurard-Levin, Zachary A., Wheeler, Benjamin D., Scholle, Michael D., Case, April W., Hirsch, Jeffrey L., Ribich, Scott, Copeland, Robert A., Boriack-Sjodin, P. Ann

Journal:

Year:

2019

Language:

english

File:

PDF, 470 KB

english, 2019

42

A Mass Spectrometric Assay of METTL3/METTL14 Methyltransferase Activity

Buker, Shane M., Gurard-Levin, Zachary A., Wheeler, Benjamin D., Scholle, Michael D., Case, April W., Hirsch, Jeffrey L., Ribich, Scott, Copeland, Robert A., Boriack-Sjodin, P. Ann

Journal:

Year:

2019

File:

PDF, 470 KB

2019